Sialosignaling
Sialylated structures are the major cancer-associated glycan alterations, including Thomsen–Friedenreich-associated antigens, sialyl Lewis antigens, α2,6-sialylated lactosamine, and gangliosides. This is due to an altered sialyltransferase expression in cancer. The presence of aberrantly sialylated structures on cell membrane receptors generates a flow of information toward the nucleus, which can exacerbate the neoplastic phenotype. Glycomatrix.com offers a variety of Lectins to detect various sylylated structures associated with cancer biomarkers.
